Fermentation and Biochemical Engineering Handbook PDF

A complete reference for fermentation engineers engaged in commercial chemical and pharmaceutical production, Fermentation and Biochemical Engineering Handbook emphasizes the operation, development and design of manufacturing processes that use fermentation, separation and purification techniques. Contributing authors from companies such as Merck, Eli Lilly, Amgen and Bristol-Myers Squibb highlight the practical aspects of the processes—data collection, scale-up parameters, equipment selection, troubleshooting, and more. They also provide relevant perspectives for the different industry sectors utilizing fermentation techniques, including chemical, pharmaceutical, food, and biofuels.

New material in the third edition covers topics relevant to modern recombinant cell fermentation, mammalian cell culture, and biorefinery, ensuring that the book will remain applicable around the globe. It uniquely demonstrates the relationships between the synthetic processes for small molecules such as active ingredients, drugs and chemicals, and the biotechnology of protein, vaccine, hormone, and antibiotic production. This major revision also includes new material on membrane pervapor.

Chapter List (270 chapters):

Chapter 1: Cover image
Chapter 2: Title page
Chapter 3: Dedication
Chapter 4: Copyright
Chapter 5: Preface to the Third Edition
Chapter 6: Preface to the Second Edition
Chapter 7: Preface to the First Edition
Chapter 8: In Memory of Henry C. Vogel
Chapter 9: List of Contributors
Chapter 10: Part I: Fermentation
Chapter 11: Chapter 1. Fermentation Pilot Plant
Chapter 12: Prologue
Chapter 13: 1.0 Microbial Fermentation
Chapter 14: Further Reading
Chapter 15: Chapter 2. Mammalian Cell Culture System
Chapter 16: 1.0 Introduction
Chapter 17: 2.0 Culture Media
Chapter 18: 3.0 Microcarrier Culture and General Control Parameters
Chapter 19: 4.0 Perfusion Culture Systems as a New High Density Culture Technology
Chapter 20: 5.0 Sedimentation Column Perfusion Systems
Chapter 21: 6.0 High Density Culture Using a Perfusion Culture System with Sedimentation Column
Chapter 22: Acknowledgment
Chapter 23: References and Bibliography (Section 2)
Chapter 24: Further Reading
Chapter 25: Chapter 3. Bioreactors for Plant Cell Tissue and Organ Cultures
Chapter 26: 1.0 Background of the Technique—Historical Overview
Chapter 27: 2.0 Media Formulations
Chapter 28: 3.0 General Applications
Chapter 29: 4.0 Bioreactors—Hardware Configuration
Chapter 30: 5.0 Bioreactor Size
Chapter 31: 6.0 Culture Period
Chapter 32: 7.0 Aeration and Agitation
Chapter 33: 8.0 Microbial Contamination
Chapter 34: 9.0 Characteristics
Chapter 35: 10.0 Manipulation
Chapter 36: 11.0 Scale-up Problems
Chapter 37: 12.0 Bioprocess Measurement and Control
Chapter 38: References (Section 3)
Chapter 39: Further Reading
Chapter 40: Chapter 4. Nutritional Requirements in Fermentation Processes
Chapter 41: 1.0 Introduction
Chapter 42: 2.0 Nutritional Requirements of the Cell
Chapter 43: 3.0 The Carbon Source
Chapter 44: 4.0 The Nitrogen and Sulfur Source
Chapter 45: 5.0 The Source of Trace and Essential Elements
Chapter 46: 6.0 The Vitamin Source and Other Growth Factors
Chapter 47: 7.0 Physical and Ionic Requirements
Chapter 48: 8.0 Media Development
Chapter 49: 9.0 Effect of Nutrient Concentration on Growth Rate
Chapter 50: References
Chapter 51: Further Reading
Chapter 52: Chapter 5. Fermentation for Biofuels and Bio-Based Chemicals
Chapter 53: 1.0 Introduction, History, and Theory
Chapter 54: 2.0 Fermentation Organism Development for a Biofuel- or Bio-Based Chemical Product
Chapter 55: 3.0 Biofuel- or Bio-Based Chemical Fermentation Process Development and Design
Chapter 56: 4.0 Practical Applications
Chapter 57: 5.0 Plant Operations
Chapter 58: 6.0 References
Chapter 59: 7.0 Examples of Biofuel- and Bio-Based Chemical Industrial Production Processes
Chapter 60: Part II: Equipment Design
Chapter 61: Chapter 6. Fermentation Design
Chapter 62: 1.0 Introduction
Chapter 63: 2.0 Fermentation Department, Equipment and Space Requirements
Chapter 64: 3.0 General Design Data
Chapter 65: 4.0 Continuous Sterilizers
Chapter 66: 5.0 Fermenter Cooling
Chapter 67: 6.0 The Design of Large Fermenters (Based on Aeration)
Chapter 68: 7.0 Troubleshooting in a Fermentation Plant
Chapter 69: 8.0 General Comments
Chapter 70: References
Chapter 71: Chapter 7. Agitation
Chapter 72: 1.0 Theory and Concepts
Chapter 73: 2.0 Pumping Capacity and Fluid Shear Rates
Chapter 74: 3.0 Mixers and Impellers
Chapter 75: 4.0 Baffles
Chapter 76: 5.0 Fluid Shear Rates
Chapter 77: 6.0 Full-Scale Plant Design
Chapter 78: 7.0 Full Scale Process Example
Chapter 79: 8.0 The Role of Cell Concentration on Mass Transfer Rate
Chapter 80: 9.0 Some Other Mass Transfer Considerations
Chapter 81: 10.0 Design Problems in Biochemical Engineering
Chapter 82: 11.0 Solution—Fermentation Problems
Chapter 83: List of Abbreviations
Chapter 84: Further Reading
Chapter 85: Part III: Recovery
Chapter 86: Chapter 8. Filtration
Chapter 87: 1.0 Introduction
Chapter 88: 2.0 Cake Filtration
Chapter 89: 3.0 Theory
Chapter 90: 4.0 Particle Size Distribution
Chapter 91: 5.0 Optimal Cake Thickness
Chapter 92: 6.0 Filter Aid
Chapter 93: 7.0 Filter Media
Chapter 94: 8.0 Equipment Selection
Chapter 95: 9.0 Continuous vs. Batch Filtration
Chapter 96: 10.0 Rotary Vacuum Drum Filter
Chapter 97: 11.0 Nutsches
Chapter 98: 12.0 BHS Autopress
Chapter 99: 13.0 Manufacturers
Chapter 100: References
Chapter 101: Further Reading
Chapter 102: Chapter 9. Cross-Flow Filtration
Chapter 103: 1.0 Introduction
Chapter 104: 2.0 Cross-flow vs. Dead End Filtration
Chapter 105: 3.0 Comparison of Cross-Flow with Other Competing Technologies
Chapter 106: 4.0 General Characteristics of Cross-Flow Filters
Chapter 107: 5.0 Operating Configurations
Chapter 108: 6.0 Process Design Aspects
Chapter 109: 7.0 Applications Overview
Chapter 110: 8.0 Glossary of Terms
Chapter 111: Acknowledgment
Chapter 112: Appendix: List of Membrane Manufacturers (Microfiltration and Ultrafiltration)
Chapter 113: References
Chapter 114: Further Reading
Chapter 115: Chapter 10. Distillation for Recovery of Biofuels and Bio-Based Chemicals
Chapter 116: 1.0 Introduction and Theory
Chapter 117: 2.0 Development of a Distillation Application
Chapter 118: 3.0 Design of a Distillation System for a New Application
Chapter 119: 4.0 Control and Automation of Distillation Systems
Chapter 120: 5.0 Distillation Plant Operations
Chapter 121: References
Chapter 122: Chapter 11. Solvent Extraction
Chapter 123: 1.0 Extraction Concepts
Chapter 124: 2.0 Distribution Data
Chapter 125: 3.0 Solvent Selection
Chapter 126: 4.0 Calculation Procedures
Chapter 127: 5.0 Drop Mechanics
Chapter 128: 6.0 Types of Extraction Equipment
Chapter 129: 7.0 Selection of Equipment
Chapter 130: 8.0 Procedure Summary
Chapter 131: 9.0 Additional Information
Chapter 132: References
Chapter 133: Chapter 12. Evaporation
Chapter 134: 1.0 Introduction
Chapter 135: 2.0 Evaporators and Evaporation Systems
Chapter 136: 3.0 Liquid Characteristics
Chapter 137: 4.0 Heat Transfer in Evaporators
Chapter 138: 5.0 Evaporator Types
Chapter 139: 6.0 Energy Considerations for Evaporation System Design
Chapter 140: 7.0 Process Control Systems for Evaporators
Chapter 141: 8.0 Evaporator Performance
Chapter 142: 9.0 Heat Sensitive Products
Chapter 143: 10.0 Installation of Evaporators
Chapter 144: 11.0 Troubleshooting Evaporation Systems
Chapter 145: References and Selected Reading Material
Chapter 146: Further Reading
Chapter 147: Chapter 13. Centrifugation
Chapter 148: 1.0 Introduction
Chapter 149: 2.0 Theory
Chapter 150: 3.0 Equipment Selection
Chapter 151: 4.0 Components of the Centrifuge
Chapter 152: 5.0 Sedimentation Centrifuges
Chapter 153: 6.0 Tubular-Bowl Centrifuges
Chapter 154: 7.0 Continuous Decanter Centrifuges (With Conveyor)
Chapter 155: 8.0 Disk Centrifuges
Chapter 156: 9.0 Filtering centrifuges vs. Sedimentation centrifuges
Chapter 157: 10.0 Filtering Centrifuges
Chapter 158: 11.0 Vertical Basket Centrifuges
Chapter 159: 12.0 Horizontal Peeler Centrifuge
Chapter 160: 13.0 Inverting Filter Centrifuge
Chapter 161: 14.0 Maintenance: Centrifuge
Chapter 162: 15.0 Safety
Chapter 163: 16.0 Pressure and Centrifugation
Chapter 164: 17.0 Manufacturers
Chapter 165: References
Chapter 166: Further Reading
Chapter 167: Chapter 14. Drying
Chapter 168: Section I. Indirect Drying
Chapter 169: Section II. Direct Drying
Chapter 170: Part IV: Purification
Chapter 171: Chapter 15. Crystallization
Chapter 172: 1.0 Introduction
Chapter 173: 2.0 Theory
Chapter 174: 3.0 Crystallization Equipment
Chapter 175: 4.0 Data Needed for Design
Chapter 176: 5.0 Special Considerations for Fermentation Processes
Chapter 177: 6.0 Method of Calculation
Chapter 178: 7.0 Troubleshooting
Chapter 179: 8.0 Summary
Chapter 180: 9.0 American Manufacturers
Chapter 181: Further Reading
Chapter 182: Chapter 16. Chromatography
Chapter 183: 1.0 Introduction
Chapter 184: 2.0 Theory
Chapter 185: 3.0 Ion Exchange Materials and Their Properties
Chapter 186: 4.0 Laboratory Evaluation of Resin
Chapter 187: 5.0 Process Considerations
Chapter 188: 6.0 Ion Exchange Operations
Chapter 189: 7.0 Industrial Chromatographic Operations
Chapter 190: References
Chapter 191: Part V: Plant Operations
Chapter 192: Chapter 17. Water Systems for Pharmaceutical Facilities
Chapter 193: 1.0 Introduction
Chapter 194: 2.0 Scope
Chapter 195: 3.0 Source of Water
Chapter 196: 4.0 Potable Water
Chapter 197: 5.0 Water Pretreatment
Chapter 198: 6.0 Multimedia Filtration
Chapter 199: 7.0 Water Softening
Chapter 200: 8.0 Activated Carbon
Chapter 201: 9.0 Ultraviolet Purification
Chapter 202: 10.0 Deionization
Chapter 203: 11.0 Purified Water
Chapter 204: 12.0 Reverse Osmosis
Chapter 205: 13.0 Water for Injection
Chapter 206: 14.0 Water System Documentation
Chapter 207: Appendix I: Existing and Proposed U.S. EPA Drinking Water Standards
Chapter 208: Appendix II: Department of Health, Education and Welfare Public Health Service
Chapter 209: References
Chapter 210: Chapter 18. Sterile Formulation
Chapter 211: 1.0 Introduction
Chapter 212: 2.0 Sterile Bulk Preparation
Chapter 213: 3.0 Isolation of Sterile Bulk Product
Chapter 214: 4.0 Crystallization
Chapter 215: 5.0 Filtering/Drying
Chapter 216: 6.0 Milling/Blending
Chapter 217: 7.0 Bulk Freeze Drying
Chapter 218: 8.0 Spray Drying
Chapter 219: 9.0 Equipment Preparation
Chapter 220: 10.0 Validation
Chapter 221: 11.0 Filling Vials with Sterile Bulk Materials
Chapter 222: 12.0 Environment
Chapter 223: 13.0 Equipment List
Chapter 224: References
Chapter 225: Chapter 19. Environmental Concerns
Chapter 226: 1.0 Environmental Regulations and Technology
Chapter 227: 2.0 Laws, Regulations and Permits
Chapter 228: 3.0 Technology (Waste Water)
Chapter 229: 4.0 Waste Water Treatment Strategy
Chapter 230: 5.0 Air (Emissions of Concern)
Chapter 231: 6.0 Selecting a Control Technology
Chapter 232: 7.0 Volatile Organic Compound (VOC) Emissions Control
Chapter 233: 8.0 Particulate Control
Chapter 234: 9.0 Inorganics
Chapter 235: Further Reading
Chapter 236: Chapter 20. Instrumentation and Control Systems
Chapter 237: 1.0 Introduction
Chapter 238: 2.0 Measurement Technology
Chapter 239: 3.0 Biosensors
Chapter 240: 4.0 Cell Mass Measurement
Chapter 241: 5.0 Chemical Composition
Chapter 242: 6.0 Dissolved Oxygen
Chapter 243: 7.0 Exhaust Gas Analysis
Chapter 244: 8.0 Measurement of pH
Chapter 245: 9.0 Water Purity
Chapter 246: 10.0 Temperature
Chapter 247: 11.0 Pressure
Chapter 248: 12.0 Mass
Chapter 249: 13.0 Mass Flow Rate
Chapter 250: 14.0 Volumetric Flow Rate
Chapter 251: 15.0 Broth Level
Chapter 252: 16.0 Regulatory Control
Chapter 253: 17.0 Dynamic Modeling
Chapter 254: 18.0 Multivariable Control
Chapter 255: 19.0 Artificial Intelligence
Chapter 256: 20.0 Distributed Control Systems
Chapter 257: References
Chapter 258: Further Reading
Chapter 259: Chapter 21. Statistical Methods for Fermentation Optimization
Chapter 260: 1.0 Introduction
Chapter 261: 2.0 Traditional One-Variable-at-a-Time Method
Chapter 262: 3.0 Design of Experiment (DOE)
Chapter 263: 4.0 Advantages of RSM
Chapter 264: 5.0 Disadvantages of RSM
Chapter 265: 6.0 Potential Difficulties with RSM
Chapter 266: 7.0 Methods to Improve the RSM Model
Chapter 267: 8.0 Summary
Chapter 268: References
Chapter 269: Further Reading
Chapter 270: Index